Dr John Mitchell - University of St Andrews

John Mitchell has a PhD in Theoretical Chemistry from Cambridge. He returned there from University College London in 2000, taking up a Lectureship in the Unilever Centre for Molecular Science Informatics. John was appointed to a Readership at St Andrews in 2009.

His recent research has centred on the interface between chemistry and biology, using computational techniques to address a diversity of problems in pharmaceutical chemistry and structural bioinformatics.  His group have worked extensively on the prediction of molecular properties such as solubility, melting point and hydrophobicity from chemical structure, using both Informatics and Theoretical Chemistry methodologies. Recently they have developed novel applications of machine learning in computational biochemistry. This includes computation of pharmaceutical activities and side effects, such as phospholipidosis, by multiple protein target prediction. They have developed the MACiE database of enzyme reaction mechanisms in collaboration with Prof. Janet Thornton at the EMBL-EBI, studying the chemical mechanisms used in enzyme catalysis. Their current work addresses the evolution of enzyme function.

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