Luke Chamberlain

Luke Chamberlain’s research focuses on the regulation of protein function by S-acylation, the post-translational attachment of acyl groups (predominantly palmitate) onto cysteine residues. Emerging evidence from diverse systems has highlighted key roles for S-acylation in regulating protein sorting, protein-protein interactions, and precise membrane micro-localisation of proteins. Research in this area was recently bolstered by the identification of a family of 24 ‘DHHC’ proteins that are responsible for the bulk of cellular S-acylation. Current work in our group aims to delineate how the activity, substrate specificity, and intracellular targeting of the DHHC protein family is regulated. We are also investigating how S-acylation regulates the function of SNARE membrane fusion proteins.

Luke Chamberlain received his PhD from the University of Liverpool. He held an independent fellowship from the Diabetes Research & Wellness Foundation and subsequently a Wellcome Trust Research Career Development fellowship at the University of Glasgow. Following this, he moved to the University of Edinburgh as an MRC senior fellow, and then to the University of Strathclyde in April 2010 as a SULSA reader in Life Sciences.

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